2024 ASCO - 预计超50项研究入选,中国精彩之声一览!
2024年美国临床肿瘤学会(ASCO)年会将于美国东部时间5月31日至6月4日在芝加哥以线上线下结合的形式召开。
摘要号:8004
Adjuvant icotinib of 12 months or 6 months versus observation following adjuvant chemotherapy for resected EGFR-mutated stage II-IIIA non-small-cell lung cancer(ICTAN, GASTO1002): A randomized phase 3 trial.
可切除EGFR突变II-IIA期非小细胞肺癌辅助化疗后埃克替尼辅助治疗12个月或6个月vs观察(ICTAN, GASTO1002):一项随机3期试验。
讲者:王思愚教授 中山大学肿瘤防治中心
摘要号:8009
Taiwan national lung cancer early detection program for heavy smokers and nonsmokers with family history of lung cancer.
台湾(中国)地区对于重度吸烟以及有肺癌家族史的非吸烟人群肺癌早期检测计划。
讲者:王菁菁(彭星辰教授团队) 四川大学华西医院
摘要号:8508
Ivonescimab combined with chemotherapy in patients with EGFR-mutant non-squamous non-small cell lung cancer who progressed on EGFR tyrosine-kinaseinhibitor treatment (HARMONi-A): A randomized, double-blind, multi-center, phase 3 trial.
依沃西单抗联合化疗用于EGFR酪氨酸激酶抑制剂(HARMONi-A)治疗进展的EGFR突变非鳞状非小细胞肺癌:一项随机、双盲、多中心、3期试验。
讲者:张力教授 中山大学肿瘤防治中心
摘要号:8008
A phase II randomized trial evaluating consolidative nivolumab in locally advanced non-small cell lung cancer post neoadjuvant chemotherapy plus nivolumab and concurrent chemoradiotherapy (GASTO-1091).
一项评估局部晚期非小细胞肺癌新辅助化疗+纳武利尤单抗和同步放化疗后纳武利尤单抗巩固治疗的II期随机试验(GASTO-1091)。
讲者:刘慧教授 中山大学肿瘤防治中心
摘要号:8502
Sacituzumab tirumotecan (SKB264/MK-2870) in combination with KL-A167 (antiPD-L1) as first-line treatment for patients with advanced NSCLC from the phase II OptiTROP-Lung01 study.
芦康沙妥珠单抗(SKB264/MK-2870)联合KL-A167(PD-L1单抗)一线治疗晚期NSCLC II期 OptiTROP-Lung01研究。
讲者:方文峰教授 中山大学肿瘤防治中心
摘要号:8014
Overall survival of adebrelimab plus chemotherapy and sequential thoracic radiotherapy as first-line treatment for extensive-stage small cell lung cancer.
阿得贝利单抗+化疗序贯胸部放疗一线治疗广泛期小细胞肺癌的总生存。
讲者:陈大卫教授 山东第一医科大学附属肿瘤医院
摘要号:8513
A multinational pivotal study of sunvozertinib in platinum pretreated non-small cell lung cancer with EGFR exon 20 insertion mutations: Primary analysis of WUKONG1 study.
舒沃替尼治疗含铂化疗失败的EGFR 20号外显子插入突变非小细胞肺癌:一项国际多中心注册临床研究,WU-KONG1研究的初步分析结果。
讲者:杨志新教授 中国国立台湾大学肿瘤中心医院
摘要号:8520
Efficacy and safety of taletrectinib in patients with advanced or metastatic ROS1+ non–small cell lung cancer: The phase 2 TRUST-I study.
他雷替尼治疗晚期或转移性ROS1+非小细胞肺癌的疗效和安全性:2期TRUST-I 研究
讲者:李玮教授 上海市肺科医院
摘要号:LBA8509
KRYSTAL-12: Phase 3 study of adagrasib versus docetaxel in patients with previously treated advanced/metastatic non-small cell lung cancer (NSCLC) harboring a KRASG12C mutation.
KRYSTAL-12:adagrasib vs 多西他赛用于经治KRASG12C突变的晚期/转移性非小细胞肺癌(NSCLC)患者的3期研究
讲者:Tony Mok教授 香港中文大学
摘要号:1020
ACE-Breast-02: A pivotal phase II/III trial of ARX788, a novel anti-HER2 antibody-drug conjugate (ADC), versus lapatinib plus capecitabine for HER2+ advanced breast cancer (ABC).
ACE-Breast-02:新型靶向HER2的抗体药物偶联物(ADC)ARX788+拉帕替尼+卡培他滨治疗HER2阳性晚期乳腺癌(ABC)的关键II/III期试验
讲者:胡夕春教授 复旦大学附属肿瘤医院
摘要号:104
Sacituzumab tirumotecan (SKB264/MK-2870) in patients (pts) with previously treated locally recurrent or metastatic triple-negative breast cancer (TNBC): Results from the phase III OptiTROP-Breast01 study.
Sacituzumab tirumotecan (SKB264/MK-2870)用于经治局部复发或转移性三阴性乳腺癌(TNBC)患者:OptiTROP-Breast01 III期研究结果
讲者:樊英教授 中国医学科学院肿瘤医院
摘要号:6002
Endostar combined with concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone for locoregionally advanced nasopharyngeal carcinoma (LA-NPC): A phase III, prospective, randomised-controlled, multicenter clinical trial.
恩度联合同步放化疗 vs 仅同步放化疗治疗局部晚期鼻咽癌(LA-NPC):一项III期、前瞻性、随机对照、多中心临床试验
讲者:康敏教授 广西医科大学第一附属医院
摘要号:6001
Tislelizumab versus placebo combined with induction chemotherapy followed by concurrent chemoradiotherapy and adjuvant tislelizumab or placebo for locoregionally advanced nasopharyngeal carcinoma: Interim analysis of a multicenter, randomized, placebo-controlled, double-blind, phase 3 trial.
替雷利珠单抗 vs 安慰剂联合诱导化疗,随后同步放化疗和替雷利珠单抗或安慰剂辅助治疗局部区域性晚期鼻咽癌:多中心,随机,安慰剂对照,双盲,3期试验中期分析结果
讲者:陈秋燕教授 中山大学肿瘤防治中心
摘要号:LBA6000
Adjuvant PD-1 blockade with camrelizumab in high-risk locoregionally advanced nasopharyngeal carcinoma (DIPPER): A multicenter, open-label, phase 3, randomized controlled trial.
卡瑞利珠单抗辅助治疗高危局部区域性晚期鼻咽癌(DIPPER):一项多中心、开放标签、3期随机对照试验
讲者:刘需教授 中山大学肿瘤防治中心
摘要号:6013
Preliminary results of phase I/II study to evaluate safety and efficacy of combination pucotenlimab with epidermal growth factor receptor-ADC (EGFR-ADC) MRG003 in patients with EGFR positive solid tumors.
评估普特利单抗联合表皮生长因子受体-ADC (EGFR-ADC)药物MRG003治疗EGFR阳性实体瘤患者安全性和有效性的I/II期研究初步结果
讲者:阮丹云教授 中山大学肿瘤防治中心
摘要号:LBA6018
Covalent FAPI PET enables accurate management of medullary thyroid carcinoma: a prospective single-arm comparative clinical trial.
共价FAPI PET促进甲状腺髓样癌精准管理:一项前瞻性、单臂临床试验
讲者:孔梓任教授 中国医学科学院肿瘤医院
摘要号:6011
Neoadjuvant sintilimab and platinum-doublet chemotherapy followed by transoral robotic surgery for HPV-associated resectable oropharyngeal cancer: Single-arm, phase II trial.
信迪利单抗+含铂双药化疗后经口机器人手术治疗HPV相关可切除口咽癌:单臂,II期试验
讲者:宋明教授 中山大学肿瘤防治中心
摘要号:LBA7003
Tucidinostat plus R-CHOP in previously untreated diffuse large B-cell lymphoma with double expression of MYC and BCL2: An interim analysis from the phase III DEB study.
西达本胺联合R-CHOP用于初治MYC和BCL2双表达弥漫性大B细胞淋巴瘤:III期DEB研究中期分析结果
讲者:赵维莅教授 上海血液学研究所
摘要号:6505
Phase I study of CN201, a novel CD3xCD19 IgG4 bispecific antibody, in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia.
新型CD3xCD19 IgG4双特异性抗体CN201用于复发或难治性B细胞急性淋巴细胞白血病成年患者的I期研究
讲者:王迎教授 中国医学科学院血液学研究所
摘要号:7002
CLAMP: A phase II prospective study of camrelizumab combined with pegaspargase, etoposide, and high-dose methotrexate in patients with natural killer (NK)/T-cell lymphoma.
CLAMP:卡瑞利珠单抗联合培门冬酶、依托泊苷和高剂量甲氨蝶呤治疗自然杀伤(NK)/ T细胞淋巴瘤的II期前瞻性研究
讲者:刘涛教授 华中科技大学同济医学院附属协和医院
摘要号:6510
Latest results of a phase 2 study of IMM01 combined with azacitidine (AZA) as the first-line treatment in adults with higher risk myelodysplastic syndromes (MDS).
IMM01联合阿扎胞苷(AZA)用于成人高危骨髓增生异常综合征(MDS)一线治疗的2期研究最新结果
讲者:杨威教授 中国医科大学附属盛京医院
摘要号:6515
CD7-CAR-T细胞治疗复发/难治性淋巴细胞白血病/淋巴瘤的安全性和有效性:I期剂量递增/扩展研究
讲者:胡利娟教授 北京大学人民医院
摘要号:7511
OriCAR-017, a novel GPRC5D-targeting CAR-T, in patients with relapsed/refractory multiple myeloma: Long term follow-up results of phase 1 study (POLARIS).
OriCAR-017,一种新型靶向GPRC5D的CAR-T,用于复发/难治性多发性骨髓瘤:1期研究(POLARIS)长期随访结果
讲者:付珊教授 浙江大学医学院附属第一医院
摘要号:7017
Timdarpacept (IMM01) in combination with tislelizumab in prior anti-PD-1 failed classical Hodgkin lymphoma: An open label, multicenter, phase II study (IMM01-04) evaluating safety as well as preliminary anti-tumor activity.
Timdarpacept (IMM01)联合替雷利珠单抗用于既往抗PD-1单抗治疗失败经典型霍奇金淋巴瘤:一项评估安全性和初步抗肿瘤活性得开放标签、多中心、II期研究(IMM01-04)
讲者:Zhenjiu Wang
摘要号:3505
Neoadjuvant treatment of IBI310 (anti-CTLA-4 antibody) plus sintilimab (anti-PD-1 antibody) in patients with microsatellite instability-high/mismatch repair-deficient colorectal cancer: Results from a randomized, open-labeled, phase Ib study.
IBI310(抗CTLA-4抗体)+信迪利单抗(抗PD-1抗体)新辅助治疗微卫星不稳定性高/错配修复缺陷结直肠癌:一项随机、开放标签、Ib期研究结果
讲者:徐瑞华教授 中山大学肿瘤防治中心
摘要号:3516
Three-year disease-free survival after transanal vs. laparoscopic total mesorectal excision for rectal cancer (TaLaR): A randomized clinical trial.
直肠癌经肛 vs 腹腔镜全直肠系膜切除术(TaLaR)后3年无病生存率:一项随机临床试验
讲者:康亮教授 中山大学附属第六医院
摘要号:3514
Phase I trial of hypoxia-responsive CEA CAR-T cell therapy in patients with heavily pretreated solid tumor via intraperitoneal or intravenous transfusion.
通过腹腔或静脉输注低氧反应性CEA CAR-T细胞治疗用于重度预处理实体瘤患者的I期试验
讲者:Hangyu Zhang 浙江大学医学院附属第一医院
摘要号:LBA3511
Total neoadjuvant treatment with long-course radiotherapy versus concurrent chemoradiotherapy in local advanced rectal cancer with high risk factors (TNTCRT): A multicenter, randomized, open-label, phase 3 trial.
全程新辅助长程放疗 vs 同步放化疗用于具有高危因素的局部晚期直肠癌新辅助治疗(TNTCRT):一项多中心、随机、开放标签3期试验。
讲者:王辛教授 四川大学华西医院
摘要号:4012
Efficacy and safety of cadonilimab in combination with pulocimab and paclitaxel as second-line therapy in patients with advanced gastric or gastroesophageal junction (G/GEJ) cancer who failed immunochemotherapy: A multicenter, double-blind, randomized trial.
卡度尼利单抗联合pulocimab和紫杉醇用于免疫化疗失败的晚期胃或胃食管交界(G/GEJ)癌患者二线治疗的有效性和安全性:一项多中心、双盲、随机试验
讲者:张小田教授 北京大学肿瘤医院
摘要号:4019
Phase I study of C-CAR031, a GPC3-specific TGFβRIIDN armored autologous CAR-T, in patients with advanced hepatocellular carcinoma (HCC).
GPC3C-TGFβRIIDN装甲型CAR-T疗法用于晚期肝细胞癌(HCC)患者的I期研究
讲者:章琦教授 浙江大学医学院附属第一医院
摘要号:4009
Efficacy of disitamab vedotin (RC48) plus tislelizumab and S-1 as first-line therapy for HER2-overexpressing advanced stomach or gastroesophageal junction adenocarcinoma: A multicenter, single-arm, phase II trial (RCTS).
维迪西妥单抗(RC48)联合替雷利珠单抗和S-1用于HER2过表达晚期胃或胃食管交界腺癌一线治疗的疗效:一项多中心、单臂、II期试验(RCTS)
讲者:刘联教授 山东大学齐鲁医院
摘要号:4010
A novel and uniquely designed bispecific antibody (LBL-024) against PD-L1 and 4-1BB in patients with advanced malignant tumors and neuroendocrine carcinoma: A report of safety and robust efficacy of LBL-024 monotherapy in phase I/II, first-in-human, open-label, multicenter, dose escalation/expansion study
一种新型、独特性设计的抗PD-L1和4-1BB双特异性抗体(LBL-024)用于晚期恶性肿瘤和神经内分泌肿瘤:I/II期、开放标签、多中心、剂量递增/扩展研究中LBL-024单药治疗的安全性和有效性结果
讲者:张盼盼教授 北京大学肿瘤医院
摘要号:4011
Safety and efficacy of IBI389, an anti-CLDN18.2/CD3 bispecific antibody, in patients with advanced pancreatic ductal adenocarcinoma: Preliminary results from a phase 1 study.
抗CLDN18.2/CD3双特异性抗体IBI389用于晚期胰腺导管腺癌的安全性和有效性:I期初步结果
讲者:郝继辉教授 天津医科大学肿瘤医院
摘要号:4511
Camrelizumab plus apatinib for previously treated advanced adrenocortical carcinoma: A single-arm, open-label, phase 2 trial.
卡瑞利珠单抗联合阿帕替尼用于经治晚期肾上腺皮质癌:单臂,开放标签,2期试验
讲者:卫治功(彭星辰教授团队) 四川大学华西医院
摘要号:2007
High-dose almonertinib in treatment-naïve EGFR-mutated NSCLC with CNS metastases: Efficacy and biomarker analysis.
高剂量阿美替尼用于CNS转移的初治EGFR突变NSCLC:疗效和生物标志物分析
讲者:范云教授 浙江省肿瘤医院
摘要号:2003
Efficacy and safety of the vebreltinib in patients with previously treated, secondary glioblastoma/IDH mutant glioblastoma with PTPRZ1-METFUsion GENe (FUGEN): A randomised, multicentre, open-label, phase II/III trial.
伯瑞替尼用于具有PTPRZ1-METFUsion GENe(FUGEN)的经治继发性胶质母细胞瘤/IDH突变型胶质母细胞瘤的疗效和安全性:一项随机、多中心、开放标签、II/III期试验。
讲者: 保肇实教授 首都医科大学附属北京天坛医院
摘要号:3008
Updated safety and efficacy data of combined KRAS G12C inhibitor (glecirasib, JAB-21822) and SHP2 inhibitor (JAB-3312) in patients with KRAS p.G12C mutated solid tumors.
KRAS G12C 抑制剂(glecirasib, JAB-21822)和SHP2抑制剂(JAB-3312)用于KRAS p.G12C突变实体瘤患者的最新安全性和有效性数据
讲者:赵军教授 北京大学肿瘤医院
摘要号:3013
9MW2821, a nectin-4 antibody-drug conjugate (ADC), in patients with advanced solid tumor: Results from a phase 1/2a study.
nectin-4抗体药物偶联物(ADC)9MW2821用于晚期实体瘤患者:1/2a期研究结果
讲者:张剑教授 复旦大学附属肿瘤医院
摘要号:3012
Results of a phase 1/2 study of MHB088C: A novel B7H3 antibody-drug conjugate (ADC) incorporating a potent DNA topoisomerase I inhibitor in recurrent or metastatic solid tumors.
MHB088C的1/2期研究结果:一种含有强效DNA拓扑异构酶I抑制剂的新型B7H3抗体-药物偶联物(ADC)用于复发或转移性实体瘤
讲者:沈琳教授 北京大学肿瘤医院
摘要号:2504
Efficacy and safety of LM-108, an anti-CCR8 monoclonal antibody, in combination with an anti-PD-1 antibody in patients with gastric cancer: Results from phase 1/2 studies
抗CCR8单克隆抗体LM-108联合抗PD-1抗体用于胃癌患者的疗效和安全性:1/2期研究结果
讲者:刘畅教授 北京大学肿瘤医院
摘要号:2501
Claudin18.2-targeted chimeric antigen receptor T cell-therapy for patients with gastrointestinal cancers: Final results of CT041-CG4006 phase 1 trial.
Claudin18.2靶向嵌合抗原受体T细胞疗法用于胃肠道肿瘤患者:CT041-CG4006 1期临床试验最终结果
讲者:齐长松教授 北京大学肿瘤医院
摘要号:2502
A potential best-in-class BCMA-CD19 bispecific CART with advanced safety by self-inhibiting IFNG signaling during CRS.
一种潜在同类最佳BCMA-CD19双特异性CART,通过在CRS期间自我抑制IFNG信号通路,显示出较好的安全性
讲者:Lei Xue 南方医科大学第三附属医院
摘要号:2518
Phase I study of GUCY2C CAR-T therapy IM96 in patients with metastatic colorectal cancer
GUCY2C CAR-T细胞治疗IM96用于转移性结直肠癌患者的I期研究
讲者:齐长松教授 北京大学肿瘤医院
摘要号:2519
Safety and preliminary efficacy results of IBI389, an anti-CLDN18.2/CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: A phase 1 dose escalation and expansion study
抗CLDN18.2/CD3双特异性抗体IBI389用于实体瘤和胃/胃食管肿瘤患者的安全性和初步疗效:一项1期剂量递增和扩展研究
讲者:Li Zheng 四川大学华西医院
摘要号:11502
Updated efficacy results of olverembatinib (HQP1351) in patients with tyrosine kinase inhibitor (TKI)-resistant succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GIST) and paraganglioma
olverembatinib (HQP1351)治疗酪氨酸激酶抑制剂(TKI)耐药琥珀酸脱氢酶(SDH)缺陷型胃肠间质瘤(GIST)和副神经节瘤的最新疗效结果
讲者:邱海波教授 中山大学肿瘤防治中心
摘要号:11507
ARTEMIS-002: Phase 2 study of HS-20093 in patients with relapsed or refractory osteosarcoma.
ARTEMIS-002: HS-20093用于复发或难治性骨肉瘤患者的2期研究
讲者:谢璐教授 北京大学人民医院
摘要号:11505
Sintilimab, doxorubicin and ifosfamide (AI) as first-line treatment in patients with advanced undifferentiated pleomorphic sarcoma (UPS), synovial sarcoma (SS), myxoid liposarcoma (MLPS) and de-differentiated liposarcoma (DDLPS): A single-arm phase 2 trial.
信迪利单抗、多柔比星和异环磷酰胺(AI)用于晚期未分化多形性肉瘤(UPS)、滑膜肉瘤(SS)、黏液样脂肪肉瘤(MLPS)和去分化脂肪肉瘤(DDLPS)一线治疗:一项单臂2期试验
讲者:罗志国教授 复旦大学附属肿瘤医院
摘要号:11518
Phase 1 study of NB003, a broad-spectrum KIT/PDGFRα inhibitor, in patients with advanced gastrointestinal stromal tumors (GIST).
NB003,一种广谱KIT/PDGFRα抑制剂,用于晚期胃肠道间质瘤(GIST)患者的I期研究
讲者:李健教授 北京大学肿瘤医院
摘要号:11515
A phase II study of anlotinib and an anti-PDL1 antibody in patients with alveolar soft part sarcoma: Results of expansion cohorts.
安罗替尼和抗PD-1抗体治疗肺泡软组织肉瘤的II期研究:扩展队列结果
讲者:谭智超教授 北京大学肿瘤医院
摘要号:12013
Effect of nurse-led multi-disciplinary treatment on patients with head and neck tumors: A randomized controlled trial.
护士主导的多学科治疗对头颈肿瘤患者的影响:一项随机对照试验
讲者:王菁菁(彭星辰教授团队) 四川大学华西医院